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Week 4 (Sept 29 - Oct 5) Chp 11 Lectures & Supplementary Information (Blanks)

Chromosome thickens nucleus of g1 phase cell enters m

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Unformatted text preview: romosome thickens, nucleus of G1 phase cell, enters M phase What happens when a S PHASE cell is fused to a G 1 PHASE cell ? G phase cell begins replicating its DNA (enters S phase) What happens when a S PHASE cell is fused to a G2 PHASE cell ? chromosomes in G2 phase cell do not replicate do not enter S phase sucks out cytoplasm inserts into different cell MICROINJECTION EXPERIMENTS (MARKERT & MASUI EXPERIMENTS) : What happens when M PHASE cytoplasm is injected into a G 2 PHASE cell ? G phase cell begins M phase What happens when INTERPHASE cytoplasm is injected into G 2 PHASE cell ? G2 phase cells remain in G2 phase What do the aforementioned experimental observations suggest? 1 regulatory molecules control entry into M and S phases 2 Molecular signals in cytoplasm of M phase cells initiate mitosis Fig. 11.14 M-Phase Promoting Factor is Created When a Cyclin Binds to a Protein Kinase CELL CYCLE ENZYMES CYCLINS increase and decrease in concentration - proteins that oscillate in concentration during the cell cycle and regulate cyclin dependent kinase activity MPF (Mitosis promoting factor) MPF - mitotic promoting factor - MPF is present in the cytoplasm and consists of two components: a protein kinase (cyclin -dependent kinase), which catalyzes the phosphorylation of a protein, and a cyclin Cdk (CYCLIN DEPENDENT KINASE) kinase adds phosphates - protein kinase, which uses ATP - adds phosphate group to protein - induces a conformational change - to be active it must be att...
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