Week 4 (Sept 29 - Oct 5) Chp 11 Lectures & Supplementary Information (Blanks)

Must be attached to cyclin phosphatase removes

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Unformatted text preview: ached to cyclin PHOSPHATASE removes phosphates (opposite of CDK) - removes phosphate group from the kinase target protein - reverses the conformational change PROTEASE DEGRADES protein - degrades proteins (proteolytic enzymes) 6 cyclin molecules combine with CDK molecules to form MPF which promotes mitosis with phosphorilation 7 Fig. 11.15 The Three Cell-Cycle Checkpoints FUNCTIONS of CELL CYCLE CHECKPOINTS - under normal conditions, cell cycle checkpoints ensure that DNA replication (S phase of Interphase) and mitosis take place only when conditions are favorable and the related processes are functioning properly - checkpoints regulate the correct sequence of events in time and enforce synchrony of different complex processes (ex. during spindle organization and chromosome contraction) - involve rapid and reversible alterations, for example when functional groups change (dephosphorylation and phosphorylation) or when proteins (cyclins) are broken down THREE MAIN CELL CYCLE CHECKPOINTS 1. G1 Checkpoint 2. G2...
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