Enzymes do not alter the reaction equilibrium but

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Unformatted text preview: eaction: CH4N2O + H2O → 2NH3 + CO2 The urease crystals contained only protein, leading Sumner to propose that all enzymes are proteins. most He received a Nobel Prize in 1946 for this discovery. Discovery of enzymes In the 1930s, Haldane postulated that weak bonding interactions between an enzyme and its substrate might be used to catalyze a reaction. This key insight lies at the heart of our current understanding of enzyme catalysis. Enzymes speed up the rates of biochemical reactions The active site of an enzyme is usually a cleft or pocket where chemistry takes place. A molecule that binds in the active site and is acted upon by the enzyme is called a substrate. As simple equation for an enzyme-catalyzed reaction can be written: E + S ES EP E + P where E is enzyme, S is substrate and P is product. Enzymes do not alter the reaction equilibrium, but they alter the forward and reverse reaction rates. Enzymes remain unchanged after the reaction. Some examples...
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