He received a nobel prize in 1946 for this discovery

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Unformatted text preview: s result from a defect or even a total absence of a particular enzyme, or excessive activity of an enzyme. Measurement of enzyme activities in body fluids is important in diagnosing various illnesses. Furthermore, many drugs act by altering the activities of enzymes. And enzymes are practical tools in the laboratory. Discovery of enzymes Buchner discovered in 1897 that yeast extracts could ferment sugar to alcohol: C6H12O6 → 2C2H5OH + 2CO2 + 2 ATP Buchner’s finding showed that fermentation was promoted by molecules that continued to function when removed from cells. Discovery of enzymes In 1926, Sumner isolated and crystallized jack bean urease, which catalyzes the reaction: CH4N2O + H2O → 2NH3 + CO2 The urease crystals contained only protein, leading Sumner to propose that all enzymes are proteins. He received a Nobel Prize in 1946 for this discovery. Discovery of enzymes In 1926, Sumner isolated and crystallized jack bean urease, which catalyzes the r...
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