BIO_325_Oct_21_08 lect 12

La te b la s tu la mbt c e n te r maternal dsh wnt 11

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Unformatted text preview: MBT C e n te r “Maternal” Dsh Wnt 11 => Fig 3.60 MBT “Zygotic” late blastula through gastrulation Signals 3 and 4 This process starts one hour before gastrulation (late blastula) and continues through gastrulation 3 = wnt & BMP inhibitors 4 = wnt8 and BMP-4 How does dorsalization work? B M P - 4 a n d w n t8 g r o w th fa c to r s a r e e x p r e s s e d b y th e m e s o d e r m c e lls w h ic h a r e o u ts id e n o t lo c a te d in th e S p e m a n n O r g a n iz e r Organizer cells secrete growth factor inhibitors = X n r-3 B M P in h ib it o r p r o t e in s e n c o d e d b y g e n e s e x p r e s s e d in t h e S p e m a n n O r g a n iz e r X nr3 Inhibitors bind BMP ligands Wnt inhibitors secreted by the SO F rz b “frisbee” Cer binding to wnt, nodal or BMP blocks their intercaction with receptors, & no signals are received by the cells Your book’s depiction Fig 3.62 BMP4 & Wnt8 gradient Fig 3.60 A multi-signal model for early development “Signal” 3 blocks Wnt8 and BMP4 High - - - Low m e s o d e r m in d u c in g s ig n a ls in e a r ly f r o g d e v e lo p m e n t BMP4 & Wnt8 gradient Fig 3....
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