This preview shows page 1. Sign up to view the full content.
Unformatted text preview: several more families and gathering some populaKon data, the same graduate student from the study above is ready to submit her thesis. Her main ﬁnding is that the disease is fairly common in society, aﬀecKng 1% of the individuals in her interview pool. ARer several more trials, she has found a new marker locus, which she calls Q, that is associated with the allele D 91% of the Kme. The alternate allele, q, is associated with non‐disease carrying individuals 99% of the Kme. What is the probability that an individual in the sample has the disease given that they possess the marker allele Q? Pr( D) = 0.01
Pr(Q D) = 0.91
Pr(q d ) = 0.99
Pr(Q) = Pr (Q D) × Pr ( D) + Pr (Q d ) × Pr( d )
Pr(Q) = 0.91(0.01) + 0.01(0.99) ≅ 0.019
Pr( D Q) = Pr ( D) × Pr (Q D)
Pr (Q) 0.01 × 0.91
0.019 MutaKonal Meltdown • The accumulaKon of mutaKons through processes such as Muller’s Ratchet can lead to a build up of deleterious mutaKons in populaKons • At high enough levels, these mutaKons can lead populaKons to decline severely in their mean ﬁtness, or ‘melt down’ • Experiments in bacteriophage suggest that those that are allowed to experience recombinaKon are less likely to experience Muller...
View Full Document
- Spring '11