assignment 3 solution


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Unformatted text preview: s Ratchet. EsKmates of Genomic MutaKon Rates •  Deleterious mutaKon rates can be esKmated using mutaKon accumulaKon experiments •  The earliest of such studies were performed in Drosophila •  As expected, viability does decline in these experiments •  From the rate of decrease in viability and the rate of increase in variaKon among replicate lines, it is possible to esKmate the total deleterious mutaKon rate, U, and the mean decrease in homozygous viability per mutaKon. •  The average rate of decline in experiments is about 0.4 per generaKon MutaKonal Load in the EnKre Genome •  Last lecture we learned about how to calculate mutaKonal load for a single locus (L=2u) •  What is the mutaKonal load for the genome as a whole? •  First, we have to assume that loci interact in some way in order to determine overall fitness •  One place to start is to assume that they interact mulKplicaKvely. •  For example, if genotype fitness due to one locus is 0.8, and due to another is 0.7, the overall fitness is 0.8 X 0.7=0.56 MutaKonal Load in the EnKre Genome •  If we assume that all loci in the genome are at mutaKon‐selecKon balance, then the overall mean (under a mulKplicaKve model) is: n w n ≅ (1 − 2µ ) •  Where w...
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This note was uploaded on 11/20/2012 for the course BIO bio3124 taught by Professor Rezanokhbeh during the Spring '11 term at University of Ottawa.

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