Lecture 10. Natural Selection II

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Unformatted text preview: r, from appropriate datasets 2‐5)Discern heterozygote phase from pedigree data 2‐6) Understand how to apply the likelihood ra+o test and calculate LOD 2‐7) Solve problems involving condi+onal probability of disease 2‐8)Understand and be able to apply the law of total probability You should be able to: 2‐9) Read likelihood graphs and determine significance of likelihood and LOD scores 2‐10) Detect the difference between an informa+ve and uninforma+ve marker 2‐11) Apply Bayes’ Theorem to disease problems 2‐12) Define natural selec+on 2‐13) Describe and solve problems involving the one locus, two allele model of selec+on 2‐14) List the assump+ons about the model of selec+on You should be able to: 2‐15) Solve problems involving the calcula+on of equilibria and their stability with respect to the selec+on model 2‐16) Describe and iden+fy the four types of selec+on 2‐17) Calculate and make predic+ons about the outcome of selec+on given a specific fitness set Muta+on Readings – chapter 6 Muta+on •  Muta+on is the source of all gene+c varia+on •  In the absence of muta+on, there would be no gene+c varia+on, and evolu+on would not occur •  In the short term, varia+on generated via muta+on tends to be negligible •  It is the long term effects and the interac+on of muta+on with selec+on and drid that make it of interest Kinds of Muta+ons any heritable change in gene+c material errors in DNA replica+on unequal crossing over chromosomal breakage meio+c non‐disjunc+on Two broad categories – gene muta+ons that map to a single locus and chromosomal muta+ons that affect the number or structure of chromosomes •  Defining gene muta+ons is complicated by the fact that most muta+ons that map to a single locus are in non‐ coding regions (and therefore do not affect a protein) •  •  •  •  •  •  Four Useful Categories of Muta+ons •  Chromosomal – change in # or structure •  Point muta+ons – change in...
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This note was uploaded on 11/20/2012 for the course BIO bio3124 taught by Professor Rezanokhbeh during the Spring '11 term at University of Ottawa.

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