Bio Notes Chapter 11

Bio Notes Chapter 11 - Chapter 11: Nucleic Acid Structure...

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Radioactive Chapter 11: Nucleic Acid Structure and DNA Replication An “informational molecule” must: -contain necessary info -be passed on to offspring -be accurate -be variable (but still accurate) DNA was identified with Frederick Griffith’s 1920’s Streptococcus experiments S. Pneumoniae causes pneumonia Variation in form: Smooth cells: external capsule shiny Rough Cells: no capsule Injected in mice -Live smooth (LS) mouse = pneumonia -Live rough (LR) mouse = no infection -Heat killed smooth (HKS) mouse = no infection -HKS and LR mouse = pneumonia and LS IN BLOOD! Found that capsules allow infection: Coined the term “transformation” – some substance from HKS transformed LR to LS, but UNKNOWN HOW 1952: Hershey and Chase infect E.coli with phage -phage coat is protein -DNA is inside “head” Labeled protein with 35 S Labeled DNA with 32 P
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-Expose bacteria to labeled phage. . spin to separate phage and E.coli Protein stays with the phage, DNA incorporated into E.coli Supports Hypothesis that DNA is informational molecule How was DNA structure determined? -Chargaff determined A:T and G:C ratios of DNA
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This note was uploaded on 04/07/2008 for the course BISC 207 taught by Professor Skopik during the Fall '07 term at University of Delaware.

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Bio Notes Chapter 11 - Chapter 11: Nucleic Acid Structure...

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