Chemistry 1004 Professor Zysmilich Lecture Notes 3.26.12

2612 wwwstudytherightwaycom 1 the action of cocaine

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Unformatted text preview: uced a medicing called “Pemberton’s French wine cocoa,” which contained cocaine and extracts of cola nuts Chemistry 1004 Professor Zysmilich Lecture Notes 3.26.12 WWW.STUDYTHERIGHTWAY.COM 1 The action of cocaine • Cocaine is an addictive drug • When a person snorts, smokes, or ingests cocaine, it travels to the brain via the bloodstream • It reaches all areas of the brain, but its euphoric effects are mediated in those areas associated with the reward penalty • Cocaine blocks dopamine re ­uptake transporters • The results in a buildup of dopamine in the synapse. In turn, this causes a continuous stimulation of receiving neurons, inducing feelings of euphoria, confidence, optimism, increased self ­esteem and sex drive • Cocaine produces an increase in the amounts of dopamine reaching the receptors • Addiction: a state in which an organism engages in a compulsive behavior, even when faced with negative consequences • Tolerance to cocaine: cells respond to the over ­stimulus of dopamine by reducing the number of dopamine receptors in them (down ­regulation) • It takes higher dose of the drug to achieve the same level of response • Dependence: develops when the neurons adapt to the repeated drug exposure and only fun...
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This note was uploaded on 12/13/2012 for the course CHEM 1004 taught by Professor Martinzysmilich during the Spring '11 term at GWU.

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