Unformatted text preview: apsule of a commercial analgesic product contains only a small amount of the
actual drug. For example, each 5 grain Bayer Aspirin tablet contains only 325 mg of aspirin.
Each Extra-Strength Excedrin tablet contains 250 mg of acetaminophen, 250 mg of aspirin, and
65 mg of caffeine. The remainder of the tablet is made up of inert fillers, such as starch, and
binders to hold everything together. This is typical of many over-the-counter and prescription
pharmaceuticals. Consequently, if one were to analyze a pharmaceutical preparation, it is often
necessary to separate the individual components from each other. One way to accomplish this is
to take advantage of the different solubilities of the individual components. For example, many
of the fillers and binders are soluble in water but not in organic solvents. On the other hand, the
active ingredients are often more soluble in organic solvents than in water. Alternatively,
different functional groups within the mixture of organic components will undergo characteristic
reactions. These differences can be used to achieve a separation.
In this experiment, you will separate the individual components of a special VCU analgesic
product called Phensuprin. The Phensuprin contains aspirin (acetylsalicylic acid) as one
analgesic component, acetanilide as another analgesic component and sucrose (table sugar) as a
filler. You will separate the individual components of the Phensuprin based upon the different
solubilities and reactivities of each component, then determine the amounts of each component
in the mixture. The purity of each component will be determined by the melting point of the
O OH OH
sucrose The first step of the separation will be based on different solubilities. Sucrose, or table sugar, is
very water soluble, but acetylsalicylic acid and acetanilide are not particularly soluble in water.
On the other hand, acetylsalicylic acid and acetanilide are soluble in dichloromethane, while
sucrose is not soluble. By first mixing the Phensuprin with dich...
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