06 Blood 2 - BLOOD TYPES BLOOD See page 745 in the text...

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BLOOD TYPES BLOOD TYPES See page 745 in the text !!!! See page 745 in the text !!!!
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What is an antibody? Protein made by B lymphocytes (plasma cells) with binding sites Specific binding of a portion of an foreign molecule (antigen) Immune system requires exposure to to the antigen to trigger the production of specific antibodies
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Antibody: Antigen binding sites Heavy Chains Heavy Chains Light Chains Light Chains
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Antibody Types Depends upon types of heavy chains - γ , μ , α , δ , ε - IgG - dimer - IgM - pentamer and first one made in sequence - IgA - in secretions, e.g., milk, saliva, intestinal - IgD - in repsonse to parasites - IgE - in allergic responses & attached to basophils
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BLOOD GROUP ANTIGENS ON RBC: SUGAR RESIDUES TRANSMEMBRANE GLYCOPROTEINS
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ABO based on ABO based on glycophorin glycophorin , , a one pass a one pass transmembrane transmembrane glycoprotein glycoprotein in in rbc rbc membranes membranes
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PROTEIN O ANTIGEN FUCOSE GALACTOSE GLUCOSE N-Ac-Glucosamine RBC
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PROTEIN Other blood types determined by the presence of one of
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