09 Blood Flow - Blood Flow Blood How does the body...

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Blood Flow Blood Flow How does the body determine distribution of blood flow (ml/min)?
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POISEUILLE’S LAW Q ( flow ml/min ) = Δ P π r 4 8 η L
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Parallel Blood Flow: Parallel Blood Flow:
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Fig 15.8
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Endothelial cell factors: EDRF ( nitric oxide or NO ) ENDOTHELIN ( peptide vasoconstrictor) Adensoine and related adenine nucleotides ( vasodilators) PURPOSE: to act locally to regulate blood flow
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Mean Average Blood Pressure (mm Hg) Mean Average Blood Pressure (mm Hg) Blood Blood Flow Flow Through Through an Arteriole an Arteriole
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% N O R M A L R E S I S T A N C E 150 100 50 40 80 120 160 MEAN ARTERIAL PRESSURE mm Hg NORMAL MAP RANGE ~ 80 - 160
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Autoregulation Myogenic mechanism Tissue metabolism –H + (lactic acid & CO 2 ) –Adenosine & adenine nucleotides –NO –Krebs cycle intermediates
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You M UST see Fig 15.12
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Fig 15.12
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Fig 15.12
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Fig 15.13
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Fig 15.14: Fig 15.14: Myogenic Myogenic Autoregulation Autoregulation
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% N O A N C E 150 150 50 50 40 80 80 120 120 160 MEAN ARTERIAL PRESSURE MEAN ARTERIAL PRESSURE Let us be certain that Let us be certain that AUTOREGULATION
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