Tissue Response to Injury Anatomy Notes

Tissue Response to Injury Anatomy Notes - by the degree of...

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Tissue Response to Injury
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Healing Process Consists of 3 phases Inflammatory response phase Fibroblastic repair phase Maturation-remodeling phase Although discussed as 3 phases the healing process occurs on a continuum There are no definitive beginnings or end points to each phase
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Inflammatory Response Stage Healing begins immediately after tissue is injured Injury to the tissue will result in cellular injury initiating the inflammatory response Signs of inflammation: Redness Swelling Tenderness Pain Warmth/Heat Loss of function
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Inflammatory Phase The initial inflammatory phase is critical to tissue healing Cellular reaction and vascular reaction
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Cellular reaction What occurs at the cellular level??? Leukocytes and phagocytes are delivered to the injured site Phagocytosis occurs – process of ingesting foreign particles and setting the stage for tissue repair
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Vascular Reaction Initial vasoconstriction (5-10 minutes) Followed by vasodilation – 24-36 hours The amount of swelling is determined
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Unformatted text preview: by the degree of vessel damage Inflammatory Phase Clot formation Platelets adhere to exposed collagen fibers and create a sticky matrix which forms a plug Initial inflammatory phase lasts approximately 2-4 days after the injury Fibroblastic Repair Phase What happens? Increase in oxygen Increase in blood flow – Granulation tissue forms with the breakdown of the fibrin clot Consist of fibroblasts Collagen Capillaries Fibroblastic Repair Phase As capillaries grow more fibroblasts accumulate Fibroblasts begin producing collagen fibers and deposit them randomly throughout the forming scar Increases tensile strength With this increase in tensile strength, the amount of fibroblasts diminish Maturation-Remodeling Phase A long-term process Collagen fibers realign or remodel according to the tensile forces applied Scar tissue is strong, but is rarely as strong as the pre-injured tissue...
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This note was uploaded on 04/07/2008 for the course HLTH 128 taught by Professor Preische during the Spring '08 term at Lock Haven.

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Tissue Response to Injury Anatomy Notes - by the degree of...

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