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Unformatted text preview: t 65 years today. Commercially produced factor
concentrates such as "Advate", a
recombinant Factor VIII produced
by Baxter International, come as a
white powder in a vial which must
be mixed with sterile water prior to
Wikipedia Gene therapy for Hemophilia B
The coding sequence for
Factor IX was inserted into
Adeno-associated viral vector
AAV’s are non-pathogenic
human viruses, ssDNA
genome of 4.7 kb
AAV8 strain infects specifically
liver cells. Factor IX was
placed under liver-specific
6 adult males with Hemophilia
B were treated
Reported levels of Factor IX
1-6% of the...
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This note was uploaded on 01/07/2013 for the course BIMM 100 taught by Professor Pasquinelli during the Spring '06 term at UCSD.
- Spring '06