hippocampus:memory (discussion1) .docx - Bigger is better...

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Bigger is better and worse: On the intricate relationship between hippocampal size and memoryABSTRACT-Suggested that larger hippocampi = less effective memory performance in healthy young adultsbecause of partial synaptic pruning-caudate volume did not correlate memory in either group-larger hippocampus = better memory (positively correlated)-but excessive unnecessary neurons/connectionsworse memoryINTRODUCTION-There may be negative correlation between hippocampal size and memory in young adults,whereas the correlation was positive in older participants-In healthy individuals: the negative correlation might be due to the incomplete synaptic pruningduring childhood and adolescenceoPruning: elimination of unnecessary neurons and synaptic connectionsoIf pruning not effective or completedlarger hippocampusless optimal forlearning/memory-Fragile X Syndrome (FXS): disease leads to intellectual disability and autismoCaused by absence of Fragile X Mental Retardation Protein (FMRP)o

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Term
Winter
Professor
John Steeves
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