BJP-2000-BECH-421-8

One trial nonusa10 was excluded after the initial

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Unformatted text preview: the authors upon request). One trial (nonUSA±10) was excluded after the initial analyses which showed that the trial was responsible for a statistically significant heterogeneity, and inspection of the results suggested that they were unlike the others (i.e., partial HDRS±17 response rates were 86.7% and 6.7% for the fluoxetine-treated and TCA-treated groups, respectively). For the USA-trial analysis, data were analysed from 16 single- and multicentre, randomised, double-blind trials involving 3543 patients (see Table 1a). Of the 3447 patients, 1914 had received fluoxetine, 847 had 107 19 43 15, 78.9 ^ 64, 59.8 ^ 356, 55.7 P ^ ^ P ^ ^ P ^ ^ D 20^80 Out ^ 54 55 109 3 USA 7 D 20^80 Out ^ 80 79 159 2 USA 8 AT 20^60 Out ^ 65 65 130 3 USA 9 P U P P 75^300 75^300 75^200 50^200 IP 20^80 In/Out ^ 62 56 118 4 USA 6 42, 53.8 ^ ^ 271, 80.6 33, 76.7 ^ ^ ^ ^ ^ 24, 38.7 38, 70.4 31, 38.7 30, 46.1 180, 63.2 263, 78.5 33, 71.7 23, 41.1 38, 69.1 41, 51.9 45, 69.2 P ^ ^ fixed AT, amitriptyline; IP, imipramine; D, doxepin; DMI, desipramine; NT, nortryptiline. Placebo TCA Fluoxetine Completers (n, %) 15, 71.4 P Published (P)/ unpublished (U) ^ ^ Dosage range (mg) TCA fixed Out 20^60 20, 40 or 60 5, 20 or 40 20 fixed 20 fixed 336 Out ^ 46 89 6 USA 5 Fluoxetine 78 Out ^ 335 671 30 USA 4 In/Out Out ^ 285 363 10 USA 3 Status (in-patient/out-patient) Placebo ^ ^ TCA 639 21 Fluoxetine 746 10 USA 2 40 1 USA 1 Total No. of patients No. of investigators Variables ^ 20, 62.5 23, 71.9 U 50^150 D 20^60 Out ^ 32 32 64 1 USA 10 ^ 6, 20.0 14, 45.2 U 75^200 D 20^60 Out ^ 30 31 61 1 USA 11 T Table 1a Description of the 16 United States (USA) clinical trials of fluoxetine v. placebo or tricyclic antidepressant (TCA) in major depression (DSM^III) able ^ 22, 73.3 23, 82.1 U 50^300 DMI 20^60 In/Out ^ 30 28 58 3 USA 12 ^ 9, 60.0 13, 86.7 U 50^150 NT 20^60 Out ^ 15 15 30 1 USA 13 ^ 25, 59.5 41, 89.1 U 50^300 DMI 20^60 Out ^ 42 46 88 2 USA 14 92, 39.1 124, 50.4 136, 55.1 P 75^300 IP 20^80 Out 235 246 247 728 7 USA 15 9, 31.0 14, 46.7 19, 63...
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