Unformatted text preview: effect. This was confirmed by the HDRS±6
In conclusion, we have shown that results from meta-analyses can differ depending on how patients who withdraw from
treatment early are counted in the analyses.
Generally, the approach used is intentionto-treat, whereby patients who withdraw
from treatment early are considered failures
in the trial group to which they were allocated, and it may be important in the future
to consider using other approaches (efficacy 427 B E CH E T AL and end-point) in meta-analyses, to determine if there is a difference. Thus, in our
analyses, we have confirmed the superiority
of fluoxetine over placebo for the shortterm treatment of major depression, and
although we were unable to show a difference in efficacy with TCAs, fewer patients
on fluoxetine withdrew due to adverse
effects. (Psychopharmacology. Series 7) (eds S. G. Dahl & L. F.
Gram), pp. 81^93. Berlin & Heidelberg: Springer-Verlag. Hedges, L.V. & Olkin, I. (1985) Statistical Methods for _ & Cialdella, P. (1992) Citalopram in depression:
meta-analysis of intended and unintended effects.
International Clinical Psychopharmacology, 6 (suppl. 5),
45^54. Hotopf, M., Hardy, R. & Lewis, G. (1997) Boissel, J. R., Blanchard, J., Panak, E., et al (1989) Considerations for the meta-analysis of randomized
clinical trials. Summary of a panel discussion. Controlled
Clinical Trials, 10, 254^281. Cohen, J. (1977) Statistical Power Analysis for the REFERENCES
American Psychiatric Association (1980) Diagnostic
and Statistical Manual of Mental Disorders (3rd edn)
(DSM ^ III).Washington, DC: APA.
Anderson, I. M. (1998) SSRIs versus tricyclic
antidepressants in depressed in-patients: A metaanalysis of efficacy and tolerability Depression and
Anxiety 7 (suppl. 1), 11^17.
omenson, B. M. (1994) The efficacy of selective serotonin re-uptake inhibitors in depression: a metaanalysis of studies against tricyclic antidepressants.
Journal of Psychopharmacology, 8, 238^249.
_ & _ (1995) Treatment discontinuation with Behavioral Sciences. Orlando, FL: Academic Press Inc. Cucherat,...
View Full Document
This note was uploaded on 01/16/2013 for the course BMS 620 taught by Professor Panavalil during the Summer '12 term at Barry Univesity.
- Summer '12