1.Serve as information carriers2.Basis for energy storage (ATP)3.Basis for enzymatic co-factors4.Basis for signaling molecules5.Mediate protein synthesis6.Pre-biotic RNA world?7.Used in research and medicine
COMMON THEMESThe SAME forces will be at work all year in BBMB 404:•HYDROPHOBIC EFFECT•H-BONDING•ELECTROSTATIC INTERACTIONS•VAN DER WAALS•…along with COVALENT BONDS
Nucleotide structure and nomenclature
The nucleotides found in vivoare derivatives of the heterocyclic, “basic”compounds purine and pyrimidine
tide: ATP5’ ATPWhat would 3’ dGMP look like?
Watson-Crick model of ds-(B form) DNA1. Antiparallel coil around a common axis2. Sugar-phosphate on the outside, bases on the inside3. Bases are perpendicular to the sugar-phosphate axis4. Translation is 3.4 Å per base, repeats every 10 bases (or 34 Å).
DNA •Anti-parallel strands•Sugar-phosphate backbone, H-bonded bases•Major groove vs. minor groove•10 bases/turn•Diameter is 20Å•Stabilizing forces