Chapter 33_316.ppt - Chapter 33 Nucleic Acids 1 2 3 4 5 6 7...

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Chapter 33: Nucleic Acids
1. Serve as information carriers 2. Basis for energy storage (ATP) 3. Basis for enzymatic co-factors 4. Basis for signaling molecules 5. Mediate protein synthesis 6. Pre-biotic RNA world? 7. Used in research and medicine
COMMON THEMES The SAME forces will be at work all year in BBMB 404: HYDROPHOBIC EFFECT H-BONDING ELECTROSTATIC INTERACTIONS VAN DER WAALS …along with COVALENT BONDS
Nucleotide structure and nomenclature
The nucleotides found in vivo are derivatives of the heterocyclic, “ basic” compounds purine and pyrimidine
Sugars in nucleic acids
Glycosidic Linkage A nucleo side 1’ 5 ’ esterification 5’ 9’ RNA: adenosine, guanosine, cytidine, uridine DNA: deoxyadenosine, deoxyguanosine, deoxycytidine, thymidine
A nucleo tide: ATP5’ ATPWhat would 3’ dGMP look like?
Watson-Crick model of ds-(B form) DNA 1. Antiparallel coil around a common axis 2. Sugar-phosphate on the outside, bases on the inside 3. Bases are perpendicular to the sugar-phosphate axis 4. Translation is 3.4 Å per base, repeats every 10 bases (or 34 Å).
DNA Anti-parallel strands Sugar-phosphate backbone, H-bonded bases Major groove vs. minor groove 10 bases/turn Diameter is 20Å Stabilizing forces

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