Lecture 10 (deleted 4f50fba2-1dcdc3-ad76d0c5)

Two maps provide more precise informa7on when used

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: th molecular markers We can use molecular markers to locate “genes of interest” in the genome through linkage. Affected and unaffected individuals are genotyped at a large number of SNPs of known map posi7on. We then test to see if there is a sta7s7cal associa7on between any SNP marker and the presence/absence of the disease phenotype. If yes, then that SNP is linked to a gene contribu7ng to the disease, and you can localize (using recombina7on freqs) that disease gene to a specific loca7on in the genome. We can now (easily) localize disease genes in the genome using molecular markers. 15 Revisit: The Maps Gene7c map Measure distance in “map units” based on recombina7on frequencies Physical map Measure distance in base pairs based on DNA sequencing Maps tell us about the loca7on of genes in the genome, using different informa7on. Two maps provide...
View Full Document

This note was uploaded on 01/30/2013 for the course BIO LS1B taught by Professor Andrewberry,hopihoekstra,maryellenruvolo during the Spring '12 term at Harvard.

Ask a homework question - tutors are online