Lecture 10 (deleted 4f50fba2-1dcdc3-ad76d0c5)

We are limited by the number of progeny we can

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Unformatted text preview: etween st and ss is: 14.6% The recombina7on frequency between ss and e is: 12.2% The recombina7on frequency between st and e is: 26.8% st 14.6 m.u. ss 12.2 m.u. e 11 A gene7c map for Drosophila The first gene7c maps were built by examining simple phenotypic traits. 12 6 2/23/12 A gene7c map for Drosophila Molecular markers Many different types Most common: Single nucleo/de polymorphisms (SNPs) We can also produce gene7c maps by genotyping molecular markers (e.g., SNPs) that do not produce visible differences in phenotype, using the same methods. 13 A gene7c map for guppies In the genomics era, iden7fying variable SNPs is straighjorward and no longer the limi7ng step in gene7c mapping. (We are limited by the number of progeny we can produce in a cross). Molecular markers are plen7ful and can be genotyped with new high ­throughput 14 sequencing technologies. Therefore, we have good gene7c maps for many species. 7 2/23/12 Mapping wi...
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This note was uploaded on 01/30/2013 for the course BIO LS1B taught by Professor Andrewberry,hopihoekstra,maryellenruvolo during the Spring '12 term at Harvard.

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