Lecture 10 (deleted 4f50fba2-1dcdc3-ad76d0c5)

H2 va vp just addi7ve gene7c varia7on both can

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Unformatted text preview: es that we observe among individual phenotypes. 36 18 2/23/12 Different types of gene7c variance • Additive ( transmissable ) genetic variance is the part of phenotypic variance that accounts for the resemblance between parents and offspring." • Dominance ( nontransmissible ) genetic variance is the part of phenotypic variance that accounts for the greater resemblance between siblings." Parent-offspring" resemblance is" related to the" transmissible! genetic variance VD The greater resemblance between " siblings is related to the " nontransmissible genetic variance VA VP = (VA + VD + VI) + VE + VGE 37 Measuring heritability: two types Broad ­sense heritability (H2) = propor7on of phenotypic variance that is due to gene7c variance. H2 = VG VP Both addi7ve and dominance gene7c varia7on H2 = 0 indicates none of the phenotypic variance is due to genotypic differences. H2 = 1 indicates that all of the phenotypic variance is due to differences in genotype. 0 < H2 < 1 indicates that both gene7c and environmental factors influence phenotype. 19 2/23/12 Broad ­sense heritability: examples Broad ­sense heritability (H2) = propor7on of phenotypic variance that is due to gene7c variance. Trait Estimated H 2 (%) Longevity Height Weight Amino acid excretion Serum lipid levels Maximum blood lactate Maximum heart rate Verbal ability...
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This note was uploaded on 01/30/2013 for the course BIO LS1B taught by Professor Andrewberry,hopihoekstra,maryellenruvolo during the Spring '12 term at Harvard.

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