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IntroANS Pharm [Spring 2011 SV] - Introductionto...

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Introduction to Autonomic System Pharmacology
Basic Principles ofNeuropharmacologyNeuropharmacology is the study of drugs that alter processes controlled by the nervous system.
The divisions of nervous systemCentral nervous systemBrain and spinal cordPeripheral nervous systemSomatic motor Autonomic ParasympatheticSympatheticPhysiology of the Nervous System
Two (2) categories of neuropharmacologic agents:Peripheral nervous system drugs*Central nervous system drugsNeuropharmacologic Agents
Synaptic transmissionInformation carried across the neuron gap and the postsynaptic cellAxonal conductionAction potential down the axonBasic Mechanism of Neuropharmacologic Agents
AUTONOMOUS, INVOLUNTARYGANGLIA OUTSIDE THE CNSAFFERENT/EFFERENT NEURONSA REFLEX SYSTEMAFFERENT - PERIPHERAL SENSORY “RECEPTORS”CNS CONTROL LARGELY BRAINSTEM AND HYPOTHALAMUSEFFERENT – TWO NEURON RELAY (GANGLION) TO RECEPTORS ON TARGET ORGANSStructural features of the ANS
PreganglionicA neuron with a cell body in the CNS and axon extending to a ganglion in the peripheryPostganglionicA neuron with a cell body in a peripheral ganglion and axon extending to a target tissueKey TermsCNSGanglionTargetTissuePreganglionicPostganglionic
Five (5) steps in synaptic transmission are:Transmitter synthesisTransmitter storageTransmitter releaseReceptor bindingTermination of transmissionSynaptic Transmission
Figure 12-2: Steps in Synaptic Transmission
Figure 13-5: Drug Structure and Receptor SelectivityMenuBFT
Neuropharmacologic drugs that act directly on the receptors can bind and Cause activatione.g., norepinephrine Prevent activatione.g., propranolol Enhance activatione.g., diazepamReceptor Binding
Fight or Flight  (NE & Epi)Heart rate increases, blood pressure risesRBCs poured into blood from spleen to carry more O2Blood flow shifted from skin and splanchnic region to skeletal musclesBlood glucose risesBronchioles and pupils dilateBrain receives signals to facilitate purposeful responses & to imprint the event in memoryRegulation of body temperature.Sympathetic System
Rest & Digest (Ach)Slows heart rate, lowers blood pressureStimulate GI movements and secretionsAids absorption of nutrientsProtects retina from excessive lightEmpties the bladder and rectumParasympathetic System
-system-showing-distribution-of

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Term
Summer
Professor
HANSON
Tags
Neurotransmitter, Cholinergic Nerve Stimulation

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