In the body sympathetic system mediated by norepinephrine

its eff e c t will n o t e xc e e d e d o 1 0 0 1 5

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Unformatted text preview: r e m e r a pi d m e t a b olis m b y ACH e s t e r a s e & its eff e c t will n o t e xc e e d e d o 1 0 0-1 5 0 μs e c So h a s n o m e di al a p plic a tio n or r ar ely u s e d :Dru g aff e c t s ACH s y n t h e si s He mic h oliniu → i n hibit c h olin tr a n sf e r s t o pr e s y n a p tic m e m b r a n e m Latro to xin “ s pi d e r toxin” a u s e r el e a s e & d e pl e tio n of ACH →c Phy s o s ti g a mi → r e v e r si bly in hibit ACH ne D-t u b o c ur a rin e r el a x a tio n of sk el e t al m u s cl e in NMJ a s it block s eff e c t ACH → of Atro pin e n o n-s el e c tiv e m u s c a rinic a n t a g o s t s → ni Bot ulin u m “toxin” in e x pir e d → p r e v e n t r el e a s e of ACH (u s e d a s t h e r a p e tic & foo d u (c o s m e tic :ty p e s of r e c e p t o r a r e a c tiv a t e d b y ACH, cl a s sifie d b y loc a tio n & fu n 2 Nicotinic r e c e p t or s.1 Sti m ul a t e d b y nico tin e o Nicto nic r e c e p t or o n g a n gli a c alle d Nn & o t h e r o n sk el e t al m u s cl e c alle d o Nm Altho u g h b o t h s ti m ul a t e d b y nico tin e t h e y c a n n o t b e block e d b y s a m e o a g e n t s G a n glio nic block er s a r e u s e d (do n o t u s e d b e c a u s e t h e y block b o t h o (g a n glio n of s y m p a t h e tic & p a r a s y m p a t h e tic (Musc a rinic r e c e p t or s (s ti m ul a t e d b y m u s c 2 rinic .a Pre s e n t o n s m o o t h m u s cl e, c ar di a c m u s cl e, gl a n d s & c h olin e r gic o (s y m p a t h e tic fib e r s (sw e a t gl a n d :ty p e s of m u s c a rinic r e c e p t o r s, 3 im p o rt a n t ­5 o M1 → i n n e rv e , g a n gli a, & GIT (pi er nz e pin e u s e d in tr e a ti n g p e p tic (u lc e r (M2 → c ar di a c ti s s u e & s m o o t h m u s cl e (g alla mi n e a n ti-M2 e ff e c t s (M3 → g l a n d s & s m o o t h m u s cl e ( e.. g, di p h e n a zin e –blockin g a g e n t Univ er s al n o n-s el e c tiv e m u s c a rinic blockin g a g e n t is a tro pin e - :Effec t of ACH or o t h e r p a r s y m p a t h o mi m e tic dr u Ey e ”Iris s p hin c t e r c o n tr a c tio n “ mio si s → o ”Ciliary m u s cl e c o n tr a t c tio n “ a c c o m d a tio n for n e a r visio n → o He a r t Br a dyc ar di→ ↓ h e a r t c o n tr a c tility a o In hi g h d o s→ ↓ blood pressure e o Bloo d v e s s el s (Blood vessels → vasodilator (via EDRF or NO2 by exogenous ACH o Lun g Bron c hi al m u s cl e c o n tr a...
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This note was uploaded on 02/04/2013 for the course MEDICINE 233 taught by Professor Ibrahim during the Spring '13 term at Jordan University of Science & Tech.

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