In the body sympathetic system mediated by norepinephrine

C tio n o s p hin c t e r r el a x a tio n o gla n d

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Unformatted text preview: c tio↑ s e cr e tio n o → n, GIT s e cr e tio n, m o tility & r el a x a tio n of s p hi↑ t e o ↑ nc r Urin ary bl a d d e r D e tr u s o r m u s cl e c o n tr a c tio n o → S p hin c t e r → r el a x a tio n o Gla n d s s w e a ti n g, ↑ l acri m a tio n, & ↑ s aliv a tio n ↑ o Par a s y m p a t h o mi m e tic a r e v e ry e ff e c tiv e in tr e a t m e n t of gl a c u c o m a or ↑IOP Glac u c o m a is d u e t o incr e a s e in pro d u c tio n of a q u e o u s h u m o r fro m ciliary o p roc e s s or d e cr e a e in a b s o r p tio n of a q u e o u s h u m o r :Tre a t m e n t o (s e cr e tio n of a q u e o u s b y β-block er (c hro nic ↓ a b s o r p tio n b y a q u e o u s b y piloc a r pin e or c ar b a c h ol ↑ Usin g c h olin e r gic a g e n t le a d t o c o n tr a c tio n of iris s p hi nc t e r s i ncr e a s e p o t e n ti al s p a c e b e t w e e n m u s cl e s & c a n al of Sc hl e m m ↑ a b s o r p tio n Usin g a n tic holin e rgic dr u g c a u s e r e tr a c tio n of s p hin c t e r → d e cr e a si n g p o t e n ti al space ”a n tic h olin er gic dr u g s a r e s e v e r ely c o n tr ai n dic a t e d in gl a u c o m a “ o :Eye - - :ACH in low d o s e will MBP ↓ o PR ↓ o ”HR “co m p e n s a t o ry eff e c t s, b y incr e a s e c o n tr a c tio n ↑ o :ACH in hi g h d o s e will Affec t v a g u s → a ff e c tin g h e a r t → b r a d y c ar di a o :Cholin e rgic a g e n t of 2 t y p e s Dir e c t a c tin g a g e n t .1 (In dir e c t a c tin g a g e n t (ACH e s t e r a s e inhibitor .2 :Direct acting agents Dire c t a c tin g a g e n t s a r e m o r e s el e c tiv e , t o m u s c a rinic or nico tinic r e c e p t o r s or b o t h :Ch e mic ally, its Cholin e s t e r s → like c a r b a c h ol & b e t h a n e c h ol (lo n g e r d u r a tio n of a c tio n, o (m o r e r e si s t a n c e t o ACH e s t e r a s e Alkaloid s → p iloc ar pin e o Dru g s with b o t h m u s c a rinic & nico tinic eff e c t in low d o s e a c tiv a t e m u s c a rinic (r e c e p t o r s b u t in hi g h d o s e will aff e c t b o t h (nico tinic & m u s c a rinic - :Met h a c h olin e Ha s s a m e e ff e c t of ACH, b u t le s s s u s c e p ti bl e t o ACH :Car b a c h ol Bot h m u s c a rinic & nico tinic e ff e c t (Not m e t a b oliz e d b y ACH e s t e r a s e (lon g d u r a tio n of a c tio n 3 0-1 2 0 mi n - Lipid s olu bl e a g e n t → u s e d in gl a u c o m a b e c a u s e its p e n e t...
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