In the body sympathetic system mediated by norepinephrine

Hic h d o mi n a n tly aff e c t m u s c a rinic r e

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Unformatted text preview: r a t e c o nju n c tiv a - :Be t h a n e c h ol Only m u s c a rinic (Not m e t a b oliz e d b y ACH (lo n g d u r a tio n of a c tio n 2 0-1 2 0 mi n Pati e n t with p a r alytic ile u s or u rin ary r e t e n tio n m u s t b e giv e n dr u g w hic h d o mi n a n tly aff e c t m u s c a rinic r e c e p t o r s → b e t h a n e c h ol :Not e s Th e s e a g e n t s s h o ul d n o t b e giv e n if t h e r e is m e c h a nic al o b s tr u c tio n in GIT or UGT; it will le a d t o ru p t ur e of ti s s u e s Org a nic block e r in b o wl + t h e s e a g e n t will le a d t o incr e a s e p e ri s t alsis o a g ai n s t n o n-m o v e a bl e or clo s e d a r e a → r u p t ur e (s a m e t hin g if t h e r e is (s t o n e in ur e t h e r a or u rin a ry r e t e n tio n b e c a u s e of pro s t a tic h y p e r tro p h y Con tr ai n dic a t e d in a s t h m a tic p a ti e n t b e c a u s e of bro n c h o-c o n s tric tio n e ff e c t Sid e e ff e c t gro u p e d in SLUDGE S → S aliv a tio n o L → L acri m a tio n o U → U rin ary u r g e n c y o D → Di arrh e a o G → GIT cr a m p s o E → E m e si s o :Piloc ar pin e Alkaloid a g e n t Re sist h y droly sis b y ACH e s t e r a s e Highly lipid s olu bl e; p e n e t r a t e c o nju n c tiv a :Us e s in (Xero s t o mi a (sjo gr e n s y n dro m e o ”Acu t e gl a u c o m a “op e n gl a u c o m a o :Be t h a n e c h ol Us e s in GIT → P ar alytic ile u s, a t o n y & m e g a c olo n o UGT → R e t e n tio n o :Sid e eff e c t s Ov er-s ti m ul a tio n of p a r a s y m p a t h e tic s y s t e m o He a r t block, v a s o dila tio n, br a d y c ar di a, h y p o t e n sio n o Urin ary u r g e n c y, di a p h or e si s, di arrh e a , & n a u s e a o :Int e r a c tio n Cholin er gic + s y m p a t h o mi m e tic a g e n t → a b olis hin g e ff e c t o Cholin e rgic + a n ti-hi s t a mi n e → a b olis hin g t h eir eff e c t ( a n ti-hi s t a mi n e h a s o (a n ti-c h olin e rgic e ff e c t s :Co n tr ain dic a tio n - Hyp e r t h yroidis m → d i arrh e a & s w e a tin g Ast h m a Pe p tic ulc e r Mec h a nic al o b s tr u c tio n of GIT OR UGT o o o o...
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This note was uploaded on 02/04/2013 for the course MEDICINE 233 taught by Professor Ibrahim during the Spring '13 term at Jordan University of Science & Tech.

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