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Unformatted text preview: iscretion. 568 t ID: Tes Do wn lo ad er ID : 42 51 Do ID Te : 56 8 st CSB349H1S Term Test 1 Answer Key 2 8 : 56 ID 425 1 st Dow nlo ade r ID: Te - P-TEFb phosphorylates Spt4/Spt5 (0.5 marks), which causes the release of NELF (0.5 marks) P-TEFb phosphorylates S2 of CTD (0.5 marks), which helps recruit other RNA processing enzymes (e.g splicing factors) while RNA Pol II is elongating (0.5 marks) Dow - nlo ade r ID: 425 1 (b) Briefly describe the two main steps that are required to overcome these negative factors and allow RNA Pol II to enter productive elongation. (2 mark) 568 t ID: 51 42 : ID er ad lo wn Do 51 : 42 ID er Do ad 568 t ID: 568 ad e 51 42 : ID er bu r ID : dd 42 y. 51 st Te st ID 56 8 nt wn lo : 51 : 42 ID er ad lo wn Do 8 de Do Test ID: 568 56 load 4251 st ID : er ID: 51 42 Te to Helicase (0.5 marks) – uses ATP to unwind DNA duplex and expose template strand (0.5 marks) Kinase (0.5 marks) – phosphorylates S5 of CTD which helps to recruit RNA capping enzymes to the CTD 4251 ader ID: Downlo : ID...
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