4pts more excitable because the cell has fewer

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Unformatted text preview: he table below, place an “o” in the boxes which are correct matches. Place an “x” in those that are not correct. (12 pts) ionotropic metabotropic requires energy x o ligand gated o o leads to ion fluxes through channels o o long lasting x o o x x o Rapid response Amplified response to ligand 4. One possible consequence of drug addiction is a significant change in the population of postsynaptic receptor molecules. Postsynaptic cells experiencing chronic over- activation of receptors, reduce the number of those receptors present (they down- regulate the receptors). Those experiencing chronic under- activation increase the number of receptors (they up- regulate the receptors). (a) Benzodiazepine mimics GABA, a neurotransmitter that inhibits postsynaptic cells. What would happen to the receptor population with chronic benzodiazepine use?(4 pts) Down regulate GABA receptors (thus the receptor population will be smaller). (b) Selective serotonin re- uptake inhibitors (SSRIs) block the recovery of the excitatory neurotransmitter serotonin from the synaptic cleft. What would happen to the receptor population with chronic SSRI use?(4 pts) Down regulate post- synaptic receptor population because of longer residence time of serotonin (lower reuptake) (c) Would the postsynaptic cell be more or less excitable upon rapid withdrawal of benzodiazepine following chronic use? (4pts) More excitable because the cell has fewer receptors for the inhibitory neurotransmitter GABA (d) Would the postsynaptic cell be more or less excitable upon rapid withdrawal of SSRI following chronic use? (4 pts) Less excitable because the cell has fewer receptors for the excitatory neurotransmitter serotonin 4 Name (print)___________________________________ TA’s name________________ Last First Voltage (mV) 5. Below are two graphs. The top figure is a plot of the action potential. The lower figure is for a graph for the flow of Na+ and K+ ions into, or out of, a neuron. 1 2 Time (ms) 3 1 2 Time (ms) 3 4 ! outward inward Ion flow 0 0 4 (a) Place the letter “R” below the line corresponding to the resting membrane potential in the top figure. Place the letter “T” above the line corresponding to the threshold potential for vol...
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This note was uploaded on 02/11/2013 for the course BIO 220 taught by Professor Unsure during the Winter '04 term at University of Washington.

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