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Unformatted text preview: his electrochemical potential drives ATP synthesis. location of the protons: P for the positive side of the inner membrane (the intermembrane space), N for the
negative side (the matrix):
NADH Lehninger Ch. 19, p. 714
departure of protons) to another (the intermembrane
space, which becomes positively charged). To emphasize the vectorial nature of the process, the overall reac- 5HN Q ¡ NAD QH2 4HP (19–2) Amytal (a barbiturate drug), rotenone (a plant product
commonly used as an insecticide), and piericidin A (an
L ﬂow from the Fe-S 710
antibiotic) inhibit electronehninger Ch. 19, p.centers of
Complex I to ubiquinone (Table 19–4) and therefore
block the overall process of oxidative phosphorylation.
Ubiquinol (QH2, the fully reduced form; Fig. 19–2)
diffuses in the inner mitochondrial membrane from
Complex I to Complex III, where it is oxidized to Q in a Electron Transport by Protein “Wires”
Chem 135 succinate succinate
dehydrogenase fumarate Examples of
FeS Clusters: An Iron Heme: Lehninger Ch. 19, p. 715 Lehninger Ch. 19, p. 710...
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This note was uploaded on 02/12/2013 for the course CHEMISTRY 135 taught by Professor Francis during the Fall '12 term at Berkeley.
- Fall '12