Summer 2020 Class 5 Drugs acting on ANS Part 1 Ch. 30-31x - Chapter 30 Adrenergic Agonists Copyright \u00a9 2013 Wolters Kluwer Health | Lippincott

Summer 2020 Class 5 Drugs acting on ANS Part 1 Ch. 30-31x

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Copyright © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins Chapter 30: Adrenergic Agonists Chapter 30: Adrenergic Agonists
Copyright © 2020 Wolters Kluwer • All Rights Reserved Adrenergic Receptors-alpha Adrenergic Receptors-alpha Adrenergic receptors: receptor sites on effectors that respond to norepinephrine/epinephrine alpha-receptors: adrenergic receptors that are found in smooth muscles o Alpha 1-receptors found in: Blood vessels- they cause vasoconstriction and increase peripheral resistance, thus raising blood pressure Iris- they cause pupil dilation Urinary bladder, they cause the increased closure of the internal sphincter. o Alpha 2-located on presynaptic nerve membranes and act as modulators of norepinephrine release; also found on the beta cells in the pancreas,
Copyright © 2020 Wolters Kluwer • All Rights Reserved Adrenergic Receptors -Beta Adrenergic Receptors -Beta beta-receptors: adrenergic receptors that are found in the heart, lungs, and vascular smooth muscle o Beta 1-found in cardiac tissue Can stimulate increased myocardial activity and increased heart rate Responsible for increased lipolysis or breakdown of fat for energy in peripheral tissues o Beta 2-found in the smooth muscle in: Blood vessels- beta2 stimulation leads to vasodilation Bronchi- Beta2-receptors also cause dilation in the bronchi Periphery, they can cause increased muscle and liver breakdown of glycogen and increased release of glucagon from the alpha cells of the pancreas Uterus- Stimulation of beta2-receptors in the uterus results in relaxed uterine smooth muscle. o Beta 3-Beta3-receptors are found in: Adipose tissue GI tract Bladder Heart
Copyright © 2020 Wolters Kluwer • All Rights Reserved Adrenergic Agonists Adrenergic Agonists Alpha and beta receptors are the two types of adrenergic nervous system receptors Definition o Called sympathomimetic drugs because they mimic the effects of the sympathetic nervous system (SNS) o Those drugs that stimulate are referred to as adrenergic or dopaminergic agonists (stimulators) o Beta-adrenergic drugs stimulate epinephrine and norepinephrine release so that they can occupy more of the receptor sites Therapeutic and Adverse Effects o Related to their stimulation of adrenergic receptor sites o Clients taking adrenergic drugs should be instructed to take no other medications without their HCP's knowledge and approval. Many over-the- counter cold remedies and appetite suppressants contain adrenergic drugs, and use of these along with prescribed adrenergic drugs can result in overdose and serious cardiovascular or central nervous system problems. In addition, adrenergic drugs can interact with numerous other drugs to increase or decrease effects.
Copyright © 2020 Wolters Kluwer • All Rights Reserved Adrenergic Agonists Adrenergic Agonists Uses o Varies from ophthalmic preparations for dilating pupils to systemic preparations for shock o Adrenergic drugs cause an increase in heart rate and

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