Q1 - 3269557 QUESTION 1 Exocytosis and endocytosis are...

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3269557 QUESTION 1 Exocytosis and endocytosis are coupled in order to maintain a relatively constant size of the nerve terminals. Exocytosis involves an abundant array of proteins but will not be examined in much detail, and emphasis will be placed on the temporal, spatial, and concentration considerations of Ca2+ dependence with regards to endocytosis. Temporal and spatial considerations of Ca2+ dependence for endocytosis There are two different ways in which Ca2+ influences endocytosis that are distinguished based on their differing affinities for Ca2+. In both mechanisms the regulation of dynamin, a key player in the Ca2+-calcineurin pathway, appears to play an important role. Each of these events occurs in differing locations of the cell, 1) away from the active zone, and 2) at the active zone. Away from the active zone High affinity Ca2+ binding (0.1-0.5 uM) endocytosis activates the Ca2+-calcineurin pathway. The increased Ca2+ concentration leads to the association between the Ca2+-dependent phosphatase calcineurin and dynamin. The dephosphorylation of
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This note was uploaded on 04/07/2008 for the course NSCI 5461 taught by Professor Newman during the Spring '08 term at Minnesota.

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Q1 - 3269557 QUESTION 1 Exocytosis and endocytosis are...

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