Q2 - 3269557 QUESTION 2 There are many variables that contribute to the Gaussian distribution of mini EPSCs 1 Number of transmitter molecules

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3269557 QUESTION 2 There are many variables that contribute to the Gaussian distribution of mini EPSCs. 1) Number of transmitter molecules packaged in vesicle. i. If you increase the number of Ach molecules in a vesicle, you should increase the EPP. ii. Increasing the amount of time allotted for packaging before release should increase the Ach in each vesicle. ↑time =↑Ach Another variable that may contribute to the unequal packaging of vesicles could rely on the efficiency or number of available transporters in proximity of the vesicle. iii. Experimentally allowing greater time between stimulation and see if the mini EPP goes up as well. Increase the number of transporters in your medium to see how EPP is affected. 2) Complete release of transmitter molecules? Kiss and Run hypothesis i. If not all of the molecules were released, this would decrease the amplitude of the EPP. ii. Kiss and Run hypothesis would explain this. The biological mechanism behind this is not understood or characterized; in fact, its very existence is still debated. iii.
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This note was uploaded on 04/07/2008 for the course NSCI 5461 taught by Professor Newman during the Spring '08 term at Minnesota.

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Q2 - 3269557 QUESTION 2 There are many variables that contribute to the Gaussian distribution of mini EPSCs 1 Number of transmitter molecules

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