Q5 - 3269557 QUESTION 5 Hair cells show adaptation to...

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3269557 QUESTION 5 Hair cells show adaptation to prolonged displacement of stereocilia in order to maintain sensitivity to transient stimuli. The molecular mechanism of adaptation Hair cells have incredible sensitivity that has been likened to the movement of the top of the Eiffel tower by the width of your thumb! Despite this incredible sensitivity, hair cells have mechanisms of adaptation that occur quickly and continuously in response to sustained displacement. Unlike other types of receptor cells such as photoreceptors, which adapt via regulation of second messenger cascades, hair cells use a different strategy. A widely accepted model for hair cell adaptation is known as the Active Motor Model. This model holds that in response to a sustained bundle deflection, the hair cell actively modulates the tension in gating springs, tip links , to return the tension back to a resting level. There are three tenants of the active motor model: 1) adaptation is mechanical, adjusting tension in tip link, 2) the insertional plaque moves during adaptation, and 3) myosin-family motor proteins are involved. A molecular model to explain this implicates a calcium-regulated motor such as myosin
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Q5 - 3269557 QUESTION 5 Hair cells show adaptation to...

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