Q6 - 3269557 QUESTION 6 Certain patterns of synaptic...

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3269557 QUESTION 6 Certain patterns of synaptic activity can lead to a long-lasting increase in synaptic strength, known as long term potentiation (LTP). LTP can produce changes that occur within minutes, early phase LTP, along with changes that occur and last from hours to days, long lasting LTP. Both mechanisms have similar basic requirements. They both require a minimum of postsynaptic depolarization that is coupled with a presynaptic stimulus; there must be functional NMDA receptors and non-NMDA receptor voltage-gated cation channels, i.e. AMPA receptors. For either the early phase or long lasting LTP to occur, the aforementioned are critical. For long lasting LTP to occur there are additional proteins and intracellular signaling cascades that must occur. Characterization of control versus early-phase LTP Early phase LTP relies only on the activity of NMDA receptors. Glutamate binding to the AMPA receptor must occur due to presynaptic transmission, as well as a sufficient postsynaptic depolarization that can cause the expulsion of the Mg2+ block on the NMDA receptor. Removal of the Mg2+ block allows Ca2+ to enter the postsynaptic neuron leading to intracellular Ca2+ increases of the postsynaptic neuron. The presynaptic stimulus and
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Q6 - 3269557 QUESTION 6 Certain patterns of synaptic...

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