presentation older Windows Version

presentation older Windows Version - Regulation of opioid...

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Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization Li He, Jamie Fong, Mark von Zastrow and Jennifer L. Whistler
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Different opioid receptors have unique properties Mu: prototypic agonist – morphine Kappa: prototypic agonist – ketocyclazocine Delta: discovered in mouse vas deferens G protein-coupled receptors, rhodopsin class A 65% a.a. sequence homology
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Terminology Mu opioid receptor – MOR Chimera of mu opioid receptor Cytoplasmic tail replaced with residues of delta opioid receptor [D-Ala-MePhe-Gly-ol] enkephalin – DAMGO Enkephalin: endogenous opioid peptide located in short interneurons assoicated with pain pathways B2AR– unrelated GPCR Beta – 2 – andrenergic receptor Isoproterenol – iso B2AR receptor agonist
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Morphine The word "morphine" is derived from: Morpheus - the god of dreams in Greek mythology. He is the son of Hypnos,
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presentation older Windows Version - Regulation of opioid...

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