NS 115 Lecture 16 - NS 115 Lecture 16 Review of lipid...

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NS 115 Lecture 16 06/02/2008 23:46:00 Review of lipid transport: Lincoln Diner I went down to the Lincoln diner Had my breakfast there My bacon and eggs were so good Fried potatoes, none can compare Ate my food so quickly  You’d think I was in a race Fats were mixed in with saliva Antibiotic some water and lipase Fatty acids were formed in the process  Not much I would say  Bit is served as a major trigger  To release my CCK CCK does so many thinks All are worth while.  But what was important for my breakfast,  My gall bladder dumped some bile.  That bile bit off a little fat.
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Inside it, the fat would dwell. Held that fat for lipase And formed a new micelle The lipase made fatty acids  Then the micelle was quickly gone The fat had been transported  Into a chylomicron. The fat oozed to my lymph.  It’s enough to make you shiver,  Ant it began its slow journey  That ended in my liver The fat was then repackaged And placed into a VLDL From there in went to my bloodstream Everything was going so well. Apo receptors on my fat cell Were begging it to come in  But first it must be invited  By big ol’insulin
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Lipoprotein lipase was awaiting For a word from insulin. To allow the fatty acids To cross membrane and come in. The VLDL then shrunk  To a smaller IDL. It could return to the liver Or go into another body cell. If it retruned to the liver. It may again be a VLDL But if it went back to my body It could become a LDL.  It could change its apo profile And join the enemy.  If not returned to the liver It could clog my artery.  If it went back to the liver Its uptake could  be aided.  If the fats that I ate at the Lincoln Were unsaturated. 
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But if it so decided To play an evil trick on me.  It might look my whole body over  For an injured artery. As it seeped into my artery  My cells would provide a clue To signal my white blood cells To come to my rescue.  If my white cells would destroy it My health they would macimize But I’d be headed for disaster  If the LDL became oxidized. The LDL and the white cell  Might join and evil harmony  To make their home in a foam cell  And squeeze my artery. And into the ol’ foam cell  Soe calcium it would pack.  That foam cell wouldn’t stop growing 
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Until it turned into a plaque. My arteries woud scream for help  I hope its not too late. For the red blood cells might rush in  And begin to coagulate My body would be screaming from some help  To get me out of this hell  But mother nature hears my cries  And sends some HDL.
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