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MCB 244: Human Anatomy and Physiology I© University of Illinois Board of TrusteesNervous TissuePart 2: SynapsesThe material contained in these slides corresponds to your assigned readings found inChapter 12 of our text.MCB 244: Human Anatomy and Physiology I© University of Illinois Board of Trustees
MCB 244: Human Anatomy and Physiology I© University of Illinois Board of TrusteesObjectivesExamination of the molecular events at a chemical synapse.How the cumulative effects of multiple synapses affect AP generation andpropagation in a neuron.
MCB 244: Human Anatomy and Physiology I© University of Illinois Board of TrusteesSynapsesSynapse:place where a neuron connects to another neuron or an effector (gland or muscle cells)Two types: chemical and electricalChemical synapses are far more common than electrical synapsesElectrical synapsePresynaptic and postsynaptic neurons boundtogether by gap junctions (direct exchange ofintracellular components from one cell to another)Fast: no synaptic delay in passing electrical signalChemical synapseMost common type in CNSInvolves release and transmissionof chemicals from neuron to effector
MCB 244: Human Anatomy and Physiology I© University of Illinois Board of TrusteesSynapsesChemical synapsePresynaptic neuron’s axon terminalproduces signalPostsynaptic neuron/effectorreceives signalMost commonly with one of itsdendritesSynaptic cleft:small fluid-filled gapbetween the two neuronsEvents of synaptic communicationNeurotransmitter molecules releasedfrom vesicles of synaptic knob into cleftTransmitter diffuses across cleft andbinds to postsynaptic receptorsBinding of transmitter to receptorinitiates postsynaptic potential(agradedpotential)Figure 12.2
MCB 244: Human Anatomy and Physiology I© University of Illinois Board of TrusteesStep 1.A nerve impulse (action potential) travels along theaxon until it reaches the synaptic knob.

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Term
Fall
Professor
BROWN
Tags
Chemical synapse, University of Illinois Board of Trustees

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