Lect 18 CVD Part 2

14 ncep ncep atp iii risk classification and ldl chol

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Unformatted text preview: NCEP NCEP ATP III Risk Classification and LDL Chol Therapy Goals Risk Classification and LDL Chol Therapy Goals CHD and CHD equivalents (vascular disease, DM) GOAL = <100 mg/dl LDL chol Initiate drug therapy when LDL chol >130 mg/dl 2 CHD risk factors GOAL = < 130 mg/dl LDL chol Initiate drug therapy when LDL chol >160 mg/dl drug therapy when LDL chol >160 mg/dl < 2 CHD risk factors GOAL = < 160 mg/dl LDL chol Initiate drug therapy when LDL chol >190 mg/dl 15 Table 13-10b, p. 306 16 AntiAnti-Hyperlipidemic Medications Major Classes Classes Bile Bile Acid Sequestrants (Cholestyramine) interrupts interrupts enterohepatic circulation of bile acids (BA) by binding BA in gut side effects: constipation, GI complaints, metallic taste -- use liquids & fiber Nicotinic Nicotinic Acid (Niacin) VLDL VLDL production by liver side effects: flushing, uric acid, hyperglycemia, N/V -- take w/ food HMGHMG-CoA reductase inhibitors (statins such as Lovastatin, Simvastatin) inhibit inhibit rate limiting enzyme in hepatic chol synthesis side effects: hepatic dysfunction, GI upset -- take w/ food Fibric Fibric Acid derivitives (Gemfibrozil) VLDL production by liver, LPL LPL synthesis/activity for TG clearance side effects: hepatic dysfunction, GI upset -- take w/ food dysfunction, Cholesterol Cholesterol Absorption Inhibitors (Zetia) Selectively inhibits cholesterol absorption from gut FOR EXAM 17 Table 13-...
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This document was uploaded on 02/25/2013.

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