Unformatted text preview: PREDIMED Trial
Prevencion con Dieta Mediterranea
Large (n=7,447) multicenter European trial of
individuals with risk factors but free of CVD. 3
diet arms Med+VOO Med+nuts Low fat
diet arms Med+VOO, Med+nuts, Low fat.
Followed multiple years • • Decreased cellular & circulating
inflammatory biomarkers related to
cardiovascular risk (Med diet vs Low fat
diet) 2012 Pharamcol Res
Beneficial changes in apolipoproteins B, A1 and their ratio (Med diet vs Low fat diet)
2011 Atherosclerosis • Reduced diabetes incidence (up to 52% ).
After 4 yr follow-up, incidence of T2DM
was 10.1% vs 17.9% (Med diet vs Low fat).
(Med diet vs Low fat)
2011 Diabetes Care 33 Acute & Chronic Cardiac Conditions
Chronic Cardiac Conditions 34 Myocardial Infarction (MI)
Biochemical indicator: Creatine phosphokinase (CPK) enzyme
released from damaged/necrotic cells; MB CPK is a specific
isoform found in cardiac muscle cells.
liquid diet x 24 hr if patient has alertness, or N/V; OR soft to DAT w/
small frequent meals if patient is fully alert
Low cholesterol AHA/TLC guidelines
Low cholesterol, AHA/TLC guidelines
Individualize sodium level; restrict if HTN, pulmonary edema or CHF Provide nutrition counseling as appropriate for TLC and follow-up on
outpatient basis 35 Surgeries
Surgeries for Correcting Occluded
• Coronary Artery Bypass Graft (CABG)
• Angioplasty (Stent placement)
Arterial graft area is ver...
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- Spring '10
- Nutrition, Atherosclerosis, ldl cholesterol, ldl chol