Sicke Cell Abstract

Sicke Cell Abstract - Beta Hemoglobin and Sickle Cell...

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Beta Hemoglobin and Sickle Cell Anemia The episodes of pain resulting from Sickle Cell Anemia can range from mild to severe symptoms. Common symptoms are hand-foot syndrome, fatigue, paleness, shortness of breath, pain in any body organ or joint, eye problems, and yellowing of skin and eyes. The gene that encodes beta hemoglobin is found in the human genome and located on chromosome 11. This gene has 3 exons and 2 introns and is 1606 base pairs long. The coding of valine instead of glutamine in position 6 of the Hb beta chain results from the mutation of substituting thymine for adenine in the sixth codon of the beta chain. Hemoglobin (Hb) S usually carries oxygen, but begins to form semisolid aggregates when oxygen is unloaded to the tissues. The hemoglobin S aggregates distort the red blood cells and cause them to lose elasticity. At first, hemoglobin S retains its ability to return to its soluble form, and the red cells can regain their elasticity upon reoxygenation. The resulting hemoglobin has the physical properties for forming polymers under
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Sicke Cell Abstract - Beta Hemoglobin and Sickle Cell...

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