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Lecture 8 MutationsBB - Mutations Evolutionary...

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Mutations
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Evolutionary Mechanisms (Microevolution) Natural Selection Mutation Genetic Drift Gene Flow Non-random Mating
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Mutation Outline Reading: Chapter 4 (148-149) Mutation Causes and Consequences Mutation Types Frameshift Mutations Substitution Mutations (Point)
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Mutation Definition Change in structure of DNA Ultimate source for new alleles W/O mutation? No variation for natural selection to act on.
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Mutation Rates RARE Characteristic 1 mutation / 10,000 gametes 1 / 5000 offspring Only mutations in germ cells
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As an Evolutionary Mechanism? Slow! Does little to change allele freq. In combo. w/ natural selection , becomes imp. evolutionary mech.
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Cause of Mutations Spontaneous: Errors in replication Nonspontaneous: Environmental agents: UV, X-rays, chemicals
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Consequence of Mutations Change in function of allele Mutation may Harmful (deleterious) Beneficial Neutral
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Thymine, Adenine; Cytosine, Guanine
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Complementary Base Pairing A – T (U) G - C
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DNA -------> aa -------> Proteins A screw-up in the DNA affects . . .
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