Lecture 6 Antibiotics & Disease of the last century

Lecture 6 Antibiotics & Disease of the last century -...

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Discovery of Antibiotics & Disease of the last Century Lecture 6
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The early days of disease treatment Ancient people had successes with herbal and other natural remedies The Egyptians consumed the mold Penicillium to treat ailments In 1908, Paul Ehrlich synthesized the chemical Salvarsan , which later proved to be an effective treatment for syphilis Ehrlich truly found a "magic bullet"
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The discovery of antibiotics Alexander Fleming's original plate with Staphylococcus aureus In 1928, Alexander Fleming noticed a contaminant on his agar plate-- luckily he did not throw it away The fungus Penicillium notatum was the source of the antibiotic penicillin Howard Florey and Ernst Chain isolated penicillin and used it in patients They later isolated P. chrysogenum
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What is an antibiotic? Antibiosis = “against life” Antibiotic is a chemical substance produced by microorganisms which has the capacity to inhibit the growth of bacteria and even destroy bacteria Various microbes secrete these compounds to gain an advantage in their microenvironment and it is from these organisms that antibiotics are isolated Selman Waksman coined the term “antibiotic” in 1941
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Antibiotics work by interfering with some aspect of the metabolism of a microorganism, such as cell wall formation, DNA synthesis or protein synthesis Viruses lack cellular structure and metabolic processes hence antibiotics are ineffective against them Mechanism of Action
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This note was uploaded on 04/07/2008 for the course MBI 111 taught by Professor Clark during the Fall '07 term at Miami University.

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Lecture 6 Antibiotics & Disease of the last century -...

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