Differentiate stem cell in the lab and transplant

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Unformatted text preview: transplant Stem cells to neurons 1. Implant stem cells directly Allow surrounding cells to influence differentiation Make stem cells function like neurons Neurons Neurons 3. Use the patients own stem cells Treat with growth factors or cell signal agents Cause the patients stem cells to replace Cause damage tissue damage Parkinson’s Disease Parkinson’s Disease Parkinson’s Treatments Drugs that replace dopamine Many side effects Dopamine tissue transplants (dopamine Dopamine neurons) neurons) Dopamine neurons don’t survive transplantation Dopamine neurons must “connect” two regions Dopamine of the brain of Early attempts 1980s Little success - only temporary success Parkinson’s Disease Parkinson’s Treatments Fetal transplants Transplant dopamine tissue Animal models showed reduction in symptoms Human trials mid 1980s Improved function - early after transplant Increases in brain dopamine Little of no improvement after 2 years Little Some patients had accelerated symptoms Some Parkinson’s and Stem Cells Parkinson’s 1. Differentiate stem cells into dopamine...
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