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Unformatted text preview: cells Use growth factors (other agents)
Then transplant 1. Transplant stem cells directly into the brain Local cells cause differentiation - dopamine
producing Parkinson’s and Stem Cells
Parkinson’s Advantages/disadvantages of stem cell sources Neural stem cells Difficult to culture and expand
Difficult Spontaneously mature
Spontaneously Embryonic stem cells or iPS cells Culture and expand to large numbers
Culture Remain undifferentiated
Remain Capable of becoming many cell types of cells
Capable Parkinson’s and Stem Cells
Parkinson’s Umbilical cord blood stem cells and Bone marrow
stem Culture and expand well (UCBSC more difficult) Have potential to become many cell types No specific evidence these can become functional dopamine
neurons New research - McKay 2001 Embryonic stems (mouse) Produced dopamine and formed synaptic connections Parkinson’s and Stem Cells
Parkinson’s Human embryonic stem cells Private institute in Canada Producing functioning neurons in culture Using the Patients Neuronal stem cells During Brain injury - neural stem cells migrate to the site
of Current research - stimulate these stem cells TGFα - found to stimulate neural stem cell in the brain My Research later… Cardiac Disease Heart Disease - Human
Germany 2002 Stem Cell Research
Neurophysiology Lab BMSC Before Induction Early Transdifferentiation
Experiment After 12 Hours...
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This note was uploaded on 04/02/2013 for the course BIO 205 taught by Professor Dr.cady during the Spring '11 term at Bradley.
- Spring '11