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Differentiate stem cells into dopamine cells use

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Unformatted text preview: cells Use growth factors (other agents) Then transplant 1. Transplant stem cells directly into the brain Local cells cause differentiation - dopamine Local producing cells producing Parkinson’s and Stem Cells Parkinson’s Advantages/disadvantages of stem cell sources Neural stem cells Difficult to culture and expand Difficult Spontaneously mature Spontaneously Embryonic stem cells or iPS cells Culture and expand to large numbers Culture Remain undifferentiated Remain Capable of becoming many cell types of cells Capable Parkinson’s and Stem Cells Parkinson’s Umbilical cord blood stem cells and Bone marrow stem cells stem Culture and expand well (UCBSC more difficult) Have potential to become many cell types No specific evidence these can become functional dopamine No neurons neurons New research - McKay 2001 Embryonic stems (mouse) Produced dopamine and formed synaptic connections Parkinson’s and Stem Cells Parkinson’s Human embryonic stem cells Private institute in Canada Producing functioning neurons in culture Using the Patients Neuronal stem cells During Brain injury - neural stem cells migrate to the site During of injury of Current research - stimulate these stem cells TGFα - found to stimulate neural stem cell in the brain My Research later… Cardiac Disease Heart Disease - Human Study Germany 2002 Stem Cell Research Stem Bradley University Neurophysiology Lab BMSC Before Induction Early Transdifferentiation Experiment Experiment After 12 Hours...
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