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Wisconsin properties of embryonic stem cells cells

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Unformatted text preview: roperties of Embryonic Stem Cells Cells Long-term self renewal - without maturing Maintain diploid chromosome condition Produce all 3 germ layers Can integrate into fetal tissues Will continue to develop Can colonize germ line – make sperm/egg Colonogenic Genetically identical (same as original cell) Properties of Embryonic Stem Cells Expresses Oct - 4 Transcription factor activates “stemness” genes Can proliferate (remain stem cells) or induced to differentiate (mature cell) Lack the “G1” checkpoint of cell cycle ES most time in the “S” phase - synthesize DNA Sources of Adult Stem Cells Sources Brain Blood cells Fat tissue Corneal cells Muscle Tendon Skin Liver Bone Marrow Bone Marrow Stem Cells 1. Hematopoietic stem cells Hematopoietic Forms most blood cells Red/white blood cells 1. Stromal (= mesenchymal cells) cells) Mixed population of cells Bone Cartilage Fat Connective tissue Embryonic Stem Embryonic Cells Pluripoten All tissue types Grow for a year or more Remain stem cell Unless stimulated to differniate Adult Stem Cells Multipotent Limited tissue types Limited Growth Do not remain stem cells Will automatically differentiate How Do Embryonic Stem Cells Remain Stem Cells Undifferentiated Undifferentiated Early experiments - Embryonic stem cells in Early culture “differentiated” - mature spontaneously culture Early studies suggested cells “talk to each” other Cell-cell signaling compounds Cytokines How Do Stem Cells How Remain as Stem Cells...
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