These hematopoiesis cells mature and cells become

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Unformatted text preview: Cells become blood cells become Red blood cells Neutrophils Eosinophils Basophils Early Stem Cells “Open Chromatin” Early hematopoiesis - stem cells “Open chromatin” structure - many Open genes expressed genes Nonhematopoietic genes - Nonblood cell type Hematopoietic genes - Genes coding for many blood cell types coding Early Stem Cells Early Open Chromatin Open chromatin - provides “multipotentiality Open Multipotentiality (two possibilities) Multipotentiality 1. Can remain stem cells Can 2. Can become many different types of cells Can Supporting Evidence Supporting “Multipotentiality” Early hematopoietic stem cells (CD45+ cells) Express genes found in many cell types Neurons Endothelial cells Pancreatic cells Kidney Liver Heart Epithelial cells Muscle Supporting Evidence Supporting “Multipotentiality” Late hematopoietic stem cells (CD45 “-”) Mature stem cells Express hematopoietic genes only “Multipotentiality” is lost Supporting Evidence Cultured Stem Cells Differentiate Spontaneously Supporting Evidence Stem Cells Differentiate Spontaneously The Potential Uses of Stem Cells Cells Therapeutic Cloning Cancer (my work) Neurological diseases Diabetes Heart Gene Therapy Therapeutic Cloning Unfertilized human egg Half of the genetic material Eggs genetic material (DNA) is removed Cloning Nucleus from an adult cell is injected in the egg Full genetic info (DNA) Egg is “acivated” to begin dividing Chemicals, electric cahrge and growth factor...
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