Exam3Lecture4

Hormone adults epiphyseal closure no additional long

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Unformatted text preview: (normal) GH stimulates – Increases in insulin-like growth factor I Increases – Stimulates growth Alterations Hypothalamic-Pituitary System Alterations Hypersecretion of Growth Hormone Adults (epiphyseal closure) » No additional long bone growth – – – – Connective tissue proliferation Cytoplasmic matrix increases Bony proliferation results At the renal tubules » » » Increase phosphate reabsorption Increase Increased carbohydrate tolerance Increased Increased metabolic rate Increased Alterations Hypothalamic-Pituitary System Alterations Hypersecretion of Growth Hormone Adults (epiphyseal closure) - continued – – – Hyperglycemia - due to reduced glucose uptake Increased hepatic glucose production Hyperinsulinism » Resulting in insulin resistance » Diabetes mellitus Alterations Hypothalamic-Pituitary System Alterations Hypersecretion of Growth Hormone Clinical manifestations – Enlarged tongues – Edema – Increase size and activity of sebaceous and sweat Increase glands glands – Thick skin and hair – Enlarged bony proliferations » Face, hands and feet Alterations Hypothalamic-Pituitary System Alterations Hypersecretion of Growth Hormone Clinical manifestations - continued – Insulin-like growth factor I stimulates cartilaginous Insulin-like growth growth – Elongation of ribs - barrel chest – Increase in cartilage at joints » Increased arthritis – Adenoma size can cause » » » Headaches Headaches Seizures Seizures Visual dysfunctions Visual Alterations Hypothalamic-Pituitary System Alterations Hypersecretion of Grow...
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