Exam3Lecture4

Rapid excretion of large volumes dilute urine rapid 2

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Unformatted text preview: educed ADH secretion leading to 1. Rapid excretion of large volumes dilute urine Rapid 2. Causing increases in plasma osmolality Causing Increased Plasma Osmolality Activation of Thirst Activation Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Activated thirst mechanism – “Polydipsia” - excessive water drinking Urine production is increased – Normal urine output 2.4 Liter/day – Diabetes insipidus » 4 - 8 liters/day » Some cases 8 - 12 liters/day Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Rapid loss of water - urine 1. Loss of water 2. Hypernatremia (high sodium) 3. Dehydration - why??? Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Rapid loss of water - urine Dehydration – – – Water loss and with hypernatremia Leads to loss of water from cells Clinically - fluid replacement is required Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Idiopathic neurogenic diabetes insipidus – Rapid onset - “three phase syndrome” Rapid “three 1. Increased diuresis (increased urine production) Likely due to hypothalamic damage – ADH centers Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Idiopathic neurogenic diabetes insipidus – Rapid onset - “three phase syndrome” Rapid “three 2. Antidiuresis (concentration of urine) Antidiuresis Necrosis(cell death) of posterior pituitary initially leads to the Necrosis(cell release of some ADH release 2. Polypuria (elevated urine output) and polydipsia Polypuria Loss of ADH secretion Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Clinical evaluation Screening for other disorders – – – Diabetes mellitus Osmotically induced diuresis Psychogenic polydipsia » Compulsive water drinking Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Clinical evaluation – Water restriction test » Other disorders will...
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