Exam3Lecture4

Filtrate enters renal function and adh renal

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Unformatted text preview: interstitial fluid - conc. filtrate enters Renal Function and ADH Renal Interstitium Collecting Tubule Basolateral AVP Tubule Lumen Apical V2 Low Water Permeability Aquaporin 2 WATER Interstitium Collecting Tubule Basolateral AVP V2 Tubule Lumen Apical [cAMP]i Increased Water Permeability Aquaporin 2 WATER Aquaporins Aquaporins Aquaporins Aquaporins Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Two types of diabetes insipidus 1. Neurogenic (central form) » Insufficient amounts of ADH (most common) Insufficient 1. Nephrogenic (renal form) 1. » » Inadequate response to ADH Inadequate Makes ADH but doesn’t work at the kidneys Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Neurogenic form Insufficiency of ADH (vasopressin) = “antidiuretic hormone” – From the post. pituitary Specific regions – Supraoptic nuclei Supraoptic – paraventricular nuclei paraventricular – Hypothalamohypophysial To the posterior pituitary Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Neurogenic form – Lesions most commonly involved » Primary brain tumor » Hypophysectomy » Aneurysms » Thrombosis » Infections » Various head traumas Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Nephrogenic from » Acquired disorder Acquired » “idiopathic” (unexplained) – Insensitivity of collecting duct to ADH » Due to drugs or toxins » Can inhibit cAMP production Can Activates aquaporins Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Drugs implicated in nephrogenic form – Lithium (carbonate) – Anesthetics (methoxyflurane) Alterations Hypothalamic-Pituitary System Alterations Diabetes insipidus Inability to form concentrated urine (definition) Pathophysiology - Neurogenic Form Pathophysiology Neurogenic – R...
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This note was uploaded on 04/02/2013 for the course BIO 205 taught by Professor Dr.cady during the Spring '11 term at Bradley.

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