Ischemia alterations hypothalamic pituitary system

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Unformatted text preview: hypophysial system is Blood reduced in oxygen normally reduced » Increased risk to pituitary ischemia Alterations Hypothalamic-Pituitary System Alterations Hypopituitarism - Sheehan Syndrome Sequence of events postpartum pituitary Sequence infarction infarction 1. 2. 2. 3. 4. Vasospasm of artery to the pituitary Vasospasm Extended vasospasm – lead to necrosis Extended Necrosis leads to edema Necrosis Pituitary expands – blood flow is reduced Pituitary Alterations Hypothalamic-Pituitary System Alterations Hypopituitarism - Sheehan Syndrome Symptoms of hypofunction of the anterior pituitary – depends on which hormone producing cells are damaged Panhypopituitarism - (all hormones) – – – – ACTH producing cells - cortisol loss TSH - thyroid deficiency ADH - diabetes insipidus FSH/LH - gonadal failure and loss secondary sex characteristics Alterations Hypothalamic-Pituitary System Alterations Hypopituitarism Panhypopituitarism - continued – GH (growth hormone) GH » Delayed growth in children Alterations Hypothalamic-Pituitary System Alterations Hypopituitarism - Panhypopituitarism Without ACTH - cortisol insufficiency Without cortisol – – – – – – Nausea - vomiting Anorexia Fatigue Weakness hypoglycemia - increased insulin sensitivity Decreased glomerular filtration - low urine output Alterations Hypothalamic-Pituitary System Alterations Hypopituitarism - Panhypopituitarism Without TSH - dysfunction of the thyroid Without dysfunction – – – – – Cold intolerance Skin dryness Mild myxedema - dry waxy swelling on skin Lethargy Decreased metabolic rate Alterations Hypothalamic-Pituitary System Alterations Hypopituitarism - Panhypopituitarism Without FSH/LH in women – Amenorrhea Amenorrhea – Atrophic vagina, uterus and breasts Atrophic Without FSH/LH in Men – Decreased facial hair Decreased – Atrophy of the testes Atrophy – Decreased libido Decreased Alterations Hypothalamic-Pituitary System Alterat...
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